I attack the early rounds in Best Ball leagues in much the same way as I do in my normal Fantasy Football drafts. In the early rounds I will always load up on WRs and RBs. Ideally, I would like to have one of each through the first two rounds, and at least two at each position through five rounds. The more I think about it, the more I want a pick later in the first round. Yes, I will miss out on the elite talents, but I will end up with a Top-8 WR and a Top-7 RB. I feel like there is a drop-off at each position after these players, so I want to be sure to snag one at each position. The one difference for me in this format compared to a regular draft is that I am more likely to load up on running backs early. There are a lot of big play wide receivers that can be selected later in the draft, so it’s better to grab safe running backs early. Through five rounds I will usually have three running backs and two wide receivers. However, after the fifth round is where things change heavily in Best Ball formats.
After the fifth round I believe you can start to take some more chances. Additionally, unlike normal drafts, in which I advocate for waiting to pick a quarterback, I think you have to take your first QB in the middle rounds here. The reason for this is you cannot stream QBs throughout the season. In a normal league, you can pick someone up when your QB is on bye. If you wait and grab a QB late and he doesn’t work out, you can stream. If your QB gets injured, you can hit the waiver wire. That is simply not an option in this format.